Troponin I sensitive

cTnI results are used to assist in the diagnosis of acute myocardial infarction and to aid in the risk stratification of patients with acute coronary syndromes with respect to their relative risk of mortality [1-4].


The imprecision profile was determined by control samples. The within-run and total standard deviations were calculated by NCCLS EP5-A2 guidelines.

Reference ranges

Reference ranges were determined from 119 healthy subjects, in whom cardiovascular diseases were exluded by cardiac magnetic resonance imaging including a dobutamine stress test. Plasma samples were measured yielding only values below 0.020 ng/ml. Upper reference limit (99th percentile) for cTnI concentration is 0.020 ng/ml. The lowest concentration with a CV less than or equal 10% (LoQ) was 0.0031 ng/ml.

Clinical performance

Troponin level of patients with non-ST-elevation myocardial Infarction (NSTEMI), unstable angina pectoris, ST-elevation myocardial infarction, non cardiac chest pain, and others were measured.

Detection of NSTEMI was analyzed by ROC curves and the corresponding negative predictive values (NPV) and positive predictive values (PPV) are displayed in the table comparision of predictive value from ROC analysis [5].

Download Datasheet Troponin I sensitive (pdf, 258 kb)


  1. Thygesen K, Alpert JS, White HD. Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction.
    Eur Heart J. 2007;28:2525-38.
  2. The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology. Guidelines for the diagnosis and treatment of non-ST-elevation acute coronary syndromes.
    Eur Heart J 2007;28:1598-1660.
  3. Apple FS. High-sensitivty cardiac troponin assays: what analytical and clinical issues need to be addressed before introduction into clinical practice?
    Clin Chem 2010;56:886-891.
  4. Peetz D et al. Method comparison of cardiac marker assays on PATHFAST, StratusCS, Axsym, Immulite 2000, Triage, Elecsys and Cardiac reader.
    Clin Lab 2006;52:605-14.
  5. 21st International Congress of Clinical Chemistry and Laboratory Medicine,
    IFCC-WorldLab – EuroMedLab, Berlin, 15-19 May 2011.