Evaluation of severity

Presepsin correlates significantly with the degree of severity of the infection as its quantitative results increase proportionally. In fact, the studies reveal maximum correlation with the SOFA score values (clinical scoring used most frequently to evaluate organ failure). Higher values on the first day of monitoring are closely associated with a higher incidence of new organ failure and hemodynamic instability in the first 24 hours.
All together, Presepsin concentration increased with the SOFA score, the number of prevalent organ dysfunctions or failures, and the incidence of new failures of the respiratory, coagulation, liver, and kidney systems, therefore Presepsin is an early predictor of host response and mortality in septic patients. Changes in concentrations over time seem to reflect the appropriateness of antibiotic therapy [5].